| Southampton FC vs. Ipswich Town FC | 9-21-2024
Saturday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| Arsenal FC vs. Southampton FC | 10-5-2024
Saturday
TBD | Emirates Stadium in London, United Kingdom | View Tickets |
| Southampton FC vs. Leicester City FC | 10-19-2024
Saturday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| Manchester City FC vs. Southampton FC | 10-26-2024
Saturday
TBD | Etihad Stadium in Manchester, United Kingdom | View Tickets |
| Southampton FC vs. Everton FC | 11-2-2024
Saturday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| Southampton FC vs. Liverpool FC | 11-24-2024
Sunday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| Southampton FC vs. Chelsea FC | 12-4-2024
Wednesday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| Aston Villa FC vs. Southampton FC | 12-7-2024
Saturday
TBD | Villa Park in Birmingham, United Kingdom | View Tickets |
| Southampton FC vs. Tottenham Hotspur FC | 12-14-2024
Saturday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| Fulham FC vs. Southampton FC | 12-21-2024
Saturday
TBD | Craven Cottage in London, United Kingdom | View Tickets |
| Southampton FC vs. West Ham United FC | 12-26-2024
Thursday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| Crystal Palace FC vs. Southampton FC | 12-29-2024
Sunday
TBD | Selhurst Park in London, United Kingdom | View Tickets |
| Southampton FC vs. Brentford FC | 1-4-2025
Saturday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| Manchester United FC vs. Southampton FC | 1-15-2025
Wednesday
TBD | Old Trafford in Manchester, United Kingdom | View Tickets |
| Southampton FC vs. Newcastle United FC | 1-25-2025
Saturday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| Southampton FC vs. AFC Bournemouth | 2-15-2025
Saturday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| Southampton FC vs. Brighton & Hove Albion FC | 2-22-2025
Saturday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| Chelsea FC vs. Southampton FC | 2-26-2025
Wednesday
TBD | Stamford Bridge in London, United Kingdom | View Tickets |
| Liverpool FC vs. Southampton FC | 3-8-2025
Saturday
TBD | Anfield in Liverpool, United Kingdom | View Tickets |
| Southampton FC vs. Wolverhampton Wanderers | 3-15-2025
Saturday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| Southampton FC vs. Crystal Palace FC | 4-2-2025
Wednesday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| Tottenham Hotspur FC vs. Southampton FC | 4-5-2025
Saturday
TBD | Tottenham Hotspur New Stadium in London, United Kingdom | View Tickets |
| Southampton FC vs. Aston Villa FC | 4-12-2025
Saturday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| West Ham United FC vs. Southampton FC | 4-19-2025
Saturday
TBD | London Stadium At Queen Elizabeth Olympic Park in London, United Kingdom | View Tickets |
| Southampton FC vs. Fulham FC | 4-26-2025
Saturday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| Southampton FC vs. Manchester City FC | 5-10-2025
Saturday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
| Everton FC vs. Southampton FC | 5-18-2025
Sunday
TBD | Goodison Park in Liverpool, United Kingdom | View Tickets |
| Southampton FC vs. Arsenal FC | 5-25-2025
Sunday
TBD | St. Mary's Stadium in Hants, United Kingdom | View Tickets |
